The overall management of the affairs of the centre is vested with the Governing Body under the Chairmanship of the Hon’ble Chief Minister of Kerala and Vice Chairmanship of Hon’ble Minister for Health & Family Welfare, Government of Kerala and consisting of the following members.
| Hon’ble Chief Minister of Kerala | Chairman |
| Hon’ble Minister for Health and Social Justice, Kerala | Vice Chairperson |
| Secretary, H &FWD, Kerala | (Alternate Vice-Chairman) |
| Secretary., Finance Dept., Kerala | Member |
| Secretary., Planning Dept., Kerala | Member |
| Vice-Chancellor, University of Kerala | Member |
| Eminent Scientist | Member |
| Nominee, Ministry of Health & Family Welfare, Govt.of India | Member |
| Nominee, Ministry of Women and Child Development, Govt.of India | Member |
| Director, Social Welfare Department, Kerala | Member |
| Director of Medical Education, Govt. of Kerala |
Member |
| Principal, Medical College, Thiruvananthapuram |
Member |
| Director, Child Development Centre, Thiruvananthapuram |
Member Secretary |